The driveway entrance of the Botanical Garden is on Via Michele Tenore, the street named after the first director of the Botanical Garden, at the end of which is located the church of Santa Maria degli Angeli alle Croci, dating back to the late 16th century.
This entrance allows cars to enter and is therefore the access road for visitors with a mobility impairment, who can enter with their own vehicles. Upon entering, on the right, there is the SInAPSi center, Services for Active and Participatory Inclusion of Students. The avenue has a canopy formed by the fronds of the nearby collection of palms, under which a rich collection of hydrangea varieties blooms every spring.
This area of the Botanical Garden was reorganized after its foundation, with the construction of the border wall on public land. Roughly in correspondence with the wall, there was a succession of crosses used during the Via Crucis, or Stations of the Cross, by the Franciscan friars of the Santa Maria degli Angeli church.